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Factors affecting drowning
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Dont find H2O in lungs because of vasovagal nerve which makes trachea spasm. Can live longer in cold water
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Percent of oxygen that is life threatening
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Under 16%
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Cellular changes that happen with injury to tissues
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Hypoxia/anoxia, when cell swells can't operate normally. Cellular accumulations (infiltrations) are water, lipds and carbs, glycogen, and proteins, lead to swelling of cells. K leaks out of cell and Ca goes in when cell damaged.
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What affects cell membrane
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Histamine, antibodies, lymphokines, complement, and proteases
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Apoptosis vs necrosis
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Apoptisis is "dropping off", programmed cell death, need to die. Necrosis is death of cell due to unexpected or accidental cell damage
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Examples of gangrene
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Dry gangrene is coagulative necrosis, skin becomes dry, shringks and wrinkles and turns dark brown or black.
Wet develops when neutrophils invade site causing liquefactive necrosis, occurs in internal organs, foul odor. |
Postmortem changes
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Algor mortise: Decrease in body temp.
Livor mortise: Purple in lower areas Rigor mortise: 6 hours after death muscles stiffen for 12-24 hours Postmortem autolysis: Putrification: Release of enzymes and lytic substances that break body down |
Percent of fluids in different groups of people
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Women are 55%
Men are 60% |
Percent of fluids in different compartments
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Intracellular: 65%
Extracellular water 33% Interstitial : 25% of extracellular Plasma: 5-8% of extracellular Transcellular: 1-2% of extracellular |
Pressure as at the arteriole versus the venous ends of capillaries
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Arteriole net outward pressure 13.3 mmHg
Venous net inward pressure 6.7 mmHg |
Measuring fluid hemostasis in patients
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Positive balance: Input is greater than output, fluid overload
Negative balance: Input is less than output, dehydration |
Cations and anion in body fluids
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Cations: (Acids) na, K, Ca, H
Anions: (Bases): Cl-, HCO3-, PO4 3- Nonelectrolytes: (Uncharged): O2, CO2, proteins, urea, glucose |
What mechanisms maintain fluid hemostasis
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Ion transport, water movement, kidney function
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What are milliequivalents
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Molecular weight in mg/valence
Molecular weight is sum of weights of atoms in molecule |
The effect of cells of hypotonic, hypertonic, and isotonic fluids
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Hypertonic: Cell shrivels, more than 0.9% nacl
Hypotonic: Cell bursts, less than 0.9% nacl Isotonic: Gain or loss of ECF resulting in a 0.9% nacl solution |