Pathology Growth Factors and Cytokines

Secreted by platelets and growth factorsmitogenic for keratinocytes and fibroblastsstimulate keratinocyte migration and granular tissue formationbinds the EGFR

Secreted by macs, t cells, keratinocytes, etcsimilar to EGFstimulates replication of hepatocytes and most epithelial cells

Secreted by platelets, macs1. growth inhibitor for epithelial cells2. fibrogenic agent-stimulates production of collagen, fibroblast chemotaxis3. anti-inflammatory function assoc with t cellskey mediator in tissue repair

Secreted by macs, mast cells, t cells, fibroblastscontribute to wound healing responseschemotactic for fibroblasts, mitogenic f and k

Secreted by many different cellsincreases vascular permeabilityinduces blood vessels formation, healing of wounds, angiogenesis

Stimulates fibroblast growth and movementIncreases synthesis of collagenVasculogenesis and angiogenesisstored in platelets
key mediator in tissue repair

Secreted by mesenchymal cellsproliferation of hepatocytes, epithelial cells, endothelial cellsincreases cell motility, keratinocyte replication

Secreted by macrophages, mast cells, t cellsactivates Macs, regulates other cytokines, expression of adhesion moleculesmediates inflammation

Secreted by macs, endothelial cellscauses fever, neutrophil releasesimiliar actions as TNF

Produced by macschemoattaction for neutrophilsneutrophil activation

Acute phase response, systemic effectsB cell maturation to Ig secretion

Released by macs and t cellsrecruit hematopoietic elements from bone marrowactivate mature macs and granulocytesI

Stimulate mast cell growthproduction of IgEmediate hypersensitivity rxn

Production dependent on IL-4binds mast cells and eosinophils and cause degranulation

NOHistamineSerotoninProstaglandins