Pathology Correlates

Pages disease- disease of the nipplePapiloma- affect the ducts Lobules- terminal duct lobule unit

Took out a lumpFibroadenoma- opened up the lump. Cut it in half. Normal residual on the side. Younger pt- not much fatLots of white tissue- white Fibroadenoma- sliced in half. Well circumscribed lesion- pops up to surface

This is the lump

Gets name from proliferation of breast stroma- connective tissueand glandular element- squished- benighn proliferation of glandbenign tumor? can't metastisized. Why take it out? took it out to find out what it was

Gross specimen of breast tissue growing in ductIntraductal papilloma

Duct- inside is the epithelial cell arranged in hapharzard manner. In large duct- what symptom? Where ducts lead? breast ductWhy do we have breast duct? Milk Milk - lactation. Complain of bloody nipple discharge. breast disease

Fibroxystic changechanges in breast during menstrual cyclechanges happening in breast- exaggeration of this. Firbocystic- blue domed cystThis is about food. Fluid in there.

Where is the cyst? epithelial lined space with fluid inside. Non-Proliferatuve fibrocystic changePurple thing? round thing? abnormal. Calcification- helps the mammographerLittle dark purple- calcification

How many layers of cells? Ducts are almost filled up with cells- almost proliferating Proliferative Fibrocystic change

Cells in duct looking abnormalAtypical ductal hyperplasia

Whole duct filled with abnormal cellsDCISductal carcinoma in situIn Situ- all bad cells contained inside the ductWhat is the pick structure all around the the bottom? Basal membraneAll cells contained in there. What happens next? extend and break through the basement membrane. Gets a different name invading through basement membrane. Invasive carcinoma. No lymphatics or veins.

Here it is still in the duct.

Invasive Ductal Carcinoma Epithelial Cells have broken through basement membrane

Invasive ductal carcinoma - cells broken through basement membrane- now outside of ductsLymph nodes- upper outer quadrant of breast- in arm pit - axillary lymph nods see it spreads.

Peau D' orangeEdema of the arm.Right breast- Paeu enlarged skinSwollen arm- 2 are related. Inflammatory carcinoma- signs of inflammation? Red- ruboreFirm- TumorWarm- CallorHurts- DoloreThis is an inflammatory process- cancer