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Cards In This Set
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3 imp causes of dyspepsia= epigastric discomfort?
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Peptice ulcer disease, gastroesophageal reflux disease (GERD), gastritis
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Most pts with dyspepsia have what sort of cause?
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Functional (not due to a structural or biochemical cause)
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PUD often assoicated with what imp factor for infection?
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H. pylori
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Gastritis = inflammation of what?
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Gastric mucosa
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Acute gastritis can occur in setting of ____ ____ ____, like what? Or, can be due to what broad category? egs?
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*severe systemic illness
*trauma, burns, sepsis, liver, renal failure, shock *direct mucosal injury *NSAIDs, ethanol, steroids (high doses), strong alkali or acid agents |
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Pathology of acute vs chronic gastritis?
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Acute: erosison and damage to the gastric mucosa and a brisk inflamm infiltrate...damage cna be diffuse or patchy
chronic: monoculear cell infiltrates and lack of mucosal erosions |
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H. pylori is assoicated with what 3 types of chronic gastritis? Which of these is considered to be a precursor to some gastric cancers?
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Chronic active gastritis, atrophic gastritis***, type B gastritis
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Describe ulcers
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Focal areas of deep erosia thru the mucosa and in some cases, thru the submucosa...commonly occur in teh stomach and duodenum
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Duodenal ulcers vs gastric ulcers?
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Duodenal: excess gastric acid
gastric: normal or even reduced gastric acid secretion |
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What's responsible for majority of ulcers? >90% in ___ and 70-80% in?
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*H pylori
*Duodenal *Gastric |
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Chances of getting ulcers if have H pylori?
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1 in 6
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H pylori is assoicated with what two cancers? What % of people with H pylori get cancer? More common in gastric or duodenal ulcers?
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*Gastric cancer and low-grade non-Hodgkin gastric lymphoma
*1-2% *gastric |
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Failure of antireflux mechs can be due to what?
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*physiologic pathology (eg decreased pressure of teh lower esophageal sphincter
*anatomic pathology (eg presence of haital hernia)j |
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Functional (non-structural/chemical) dyspepsia coudl be due to what sorts of factors?
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Abnormalities in upper GI motor function, visceral sensitivity, variety of pscyhosocial factors
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Risk factors for h pylori are the same for what? include?
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*same as for acute gastritis!
*include male gender, NSAID use, steroid use, cigarette smoking |
