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WHAT IS AKI?
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AKI once termed acute renal failure refer to the abrupt and decreased function of the renal system which is first assess with a sudden decreased in urine output
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How is AKI assessed?
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-decreased urine output -increased BUN levels increased Cratinine levels
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If romney came in to the hpispital as a result of severe dehydration and a hemorrhage and the doctors found out she has a complete decreased in blood volume to the kidneys, this would be considered what?
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Pre-Renal injury to the kidneys
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In order to maintain normal GFR, what is activated in response to the pre-renal injury?
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The RAAS system which will get rennin to secrete aldosterone from A1 to A2 and vasoconstrictor in order to retiain sodium and water and increase BP to overall circulate more fluid throughout the body
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If romney comes to the hospital with a MAP of 60 and urine output of 25ml/hr what does this indicate
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Poor and inadequate perfusion and renal blood flow- map 65-70 and urine 25-30ml
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What happens when cardiac output drops?
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Well, the kidneys rely heavily on the cardiac output for the pressure that maintain GFR in the body. therefore, then we have a decrease in cardiac output the kidneys try and compensate through renal capillary vasoconstriction which shunts blood away from the kidneys and increases blood supply to other, more critical organs
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Which medication should we AVOID in patient with a pre-renal injury?
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NSAIDS- we avoid these because they inhibit prostaglandin synthesis and which are important mediators of glomerular afferent arteriole vasodilation and NSAIDS also can decrease pressure in the GFR
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What in Intrinsic Renal Injury? causes?
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Caused by problems that target the renal parenchyma
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Which drugs are toxic to the kidneys?
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Moysins= antiinfective because they are toxic to the nephrons in the kidneys
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What drugs are toxic to renal tubules?
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Aminoglycosides and lithium
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Which drugs are toxic to renal interstitial?
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NSAIDS and proton pump inhibitos
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What is hepatorenal syndrome?
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This is a coomlication of advanced liver disease that causes severe renal insufficiency
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Hepatorenal syndrome
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Hepatorenal syndrome (HRS) is a type of progressive kidney failure seen in people with severe liver damage, most often caused by cirrhosis. As the kidneys stop functioning, toxins begin to build up in the body. Eventually, this leads to liver failure.
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What type of kidney injury would be caused from hypovolemic shock (reduced circulating fluid in the body?)
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Pre-renal injury
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Azotemia?
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This refers to rapidly elevated nitrogen waste in the blood with increased K
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