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Variola
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Smallpox
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Edward Jenner
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Used cowpox for small pox vaccine
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Last case of small pox on earth
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1977 somalia
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Disease eradicated with vaccines
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Small pox
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3 ways to get out of vaccines
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Medical, religious, philosophical
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Humoral response
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B cells
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Celluar response
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T cells
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Live vaccines (7)
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Herpes zoster, varicella, typhoid, yellow fever, rotavirus, LAIV, MMR
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Difference between live and inactivated
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Live must replicate to work
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Herd immunity
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Vaccinate large amounts of people
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Cocooning
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Vaccinate ring of people around, esp for pertussis when infant cannot be vaccinated <2months
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Two types of inactivated vaccines
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Polysaccharide and conjugate
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T-Cell Independent Immunity
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T helper cells not used to stimulate B cells: short lived immunity, no booster effect, IgM, Polysaccharide Vaccine
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T-Cell Dependent Immunity
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Produces immunologic memory, booster effect present when exposed again, IgG, long term antibodies, conjugate polysaccharide
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Most frequent complication of influenza
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Pneumonia
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