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What are the types of Malaria that infect humans
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1. Falciparum
2. Vivax 3. Ovale 4. Malariae |
How is malaria transmitted to humans?
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Through a bite from a female anopholes mosquito
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What is meant by "malaria endemic"?
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This refers to areas where the numbers of Malaria cases remains relatively constant through out all seasons.
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How many cases of Malaria do we see in Australia?
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600-800 per year
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How do we manage resistance to anti-Malarial drugs?
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By using combination therapy with artemesinin combination therapies.
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How is "vector control" managed in the prevention of malaria?
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1. mosquito nets treated with insecticides
2. indoor residual spraying of insecticides |
What are the phases of Malaria infection?
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1. Prepatent : between sporozoite inoculation and parasite detection in blood.
2. Incubation: between infection and symptoms 3. Paroxysms : cyclical manifestations of symptoms as a result of invasion of blood by new merozoites 4. Periodicity: regular recurrence of paroxysms 5. Relape: recurrence of parasites from hypnozoites 6. Recrudescence: renewed infection due to survival of rbc forms. |
Falciparum's features?
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Incubation 8-15 days
Paroxysms <48 hrs % rbcs infected 50% course if untreated 1 yr stage in peripheral blood: rings and gametocytes |
Vivax features?
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Incubation 10-15 days
Paroxysms 48hrs % rbcs infected 2-3% Course if untreated 3yrs Stages seen in peripheral blood: all |
Ovale features?
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Incubation 15 days
Paroxysms 48hrs % rbcs infected 2-3% Course if untreated 3 yrs Stages seen in peripheral blood: all |
Malariae features?
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Incubation 20-40 days
Paroxysms 72hrs % rbcs infected <1% Course if untreated: many Stages seen in peripheral blood: all |