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Step one
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Unstable acetyl CoA bond breaks, CoA relased acetyl group bonds 4-C oxaloacetate -> 6-C Citrate
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Step two
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H20 is removed, another is added back to convert citrate to its isomer, isocitrate
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Step three
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Isocitrate loses CO2 and remaining 5-C is oxidized (ketoglutarate) to reduce NAD+ to NADH
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Step four
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Multienz. compx catalyzes: removal of C02, oxidat. of 4-C compound to reduce NAD+ to NADH, CoA attaches to high energy bond to make succinyl CoA
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Step five
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Phosphate group is transferred to GDP (->GTP) and then to ADP (->ATP). Remain 4-C compound is succinate
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Step six
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Succinate is oxidized into fumarate as 2Hs are transferred to FAD (->FADH2)
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Step seven
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Water is added to fumarate which rearranges its bonds to become malate
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Step eight
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Malate is oxidized into oxaloacetate as 1H is transferred to NAD (->NADH)
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