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Related Flashcards
Cards In This Set
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Whati is SLE?
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This is an autoimmune disorder that is charecterized by inflammaiton and autoantibodies that develop against nuclear antigens
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What are the 2 disease patterns of SLE?
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1. Relapsing and Remitting ("flare up")2. continuously active disease
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What is SLE trugger by?
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-IV lights_drugs ( Isonazie, hydralazine, procainmide)
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Which drugs are though to trigger SLE?
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-isonazine-procainide-hyralazine
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How does estrogen cause SLE?
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Estrogen seems to foster the developemnt of SLe by enhancing helper T cells functioning and weakening the supressor T-cell fucntion and results in increased producito of autoantibodies which taget DNA, platelts, RBC
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What is SLE ?
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A strong type 3 hypersensitivty reaciton-antigen-antibodies deposit in the epithelial lining of the blood vessels and tissue furfaces
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What do the depositics that are created by antigen=antibodies do?
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-these depositcs can create an occlusion which leads to tissue death and scar formation which eventually leads to impaired organ funciton
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What are some symptoms of SLE?
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-malaise-fatigeue-fever-weight loss-joint pain-skin manifestations
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What ar the most common organs attacked from SLE?
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1. vascualr2. cardiopulmonary3. renal
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Dx of SLE?
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Dx can de difficult and therefore, Drug induced etiology is first ruled out through close examination of the patient drugs there taking
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Drug tests used for SLE?
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There is no specific drug test thats used for SLE however the msot common drug test used to rule our SLE is the antigen-Nuclear antibody test (ANA)
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Which manifestatoins in the ANA ued for?
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1. sleridoma2. Rhumatic arthritis
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How do we Dx SLE?
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1. we need a ELEVATED titer levels and 4 of the following: present to rule out sLE:-arthritis--hem dis-imm dis-neuro dis-renal dis-seritisi-anti nul-discoid rash-malr rash-orl rashphoto srash
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If aden has Lupus as well as a dermatological skin proble, how would we treat her?
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-NSAIDS and antimalarial drugs-hydrochloroquine
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What are unconctrolled lupus flares treated with?
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Methotrexaterituxumabmycophenalatecyclophosphamideazathioprine
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