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Cards In This Set
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Desrcribe RA
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Symmetric, inflamm peipheral polyarthritis characterized by lymphocytic infilitration of the synovial joints and granulomatous extra-articular nodules
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Peak age of onset? more common in women or men? strongly related to?
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40-50; more common in women (3:1); fam hx
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In RA, ___ __ cells become activated, leading to a cascade of ___ that causes the ___ lining to become ___, causing ___ adn ___ of the ___ ___.
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Synovial T; inflammation; synovial; invasive; erosion; destruction; joint cartilage
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Inflammation is accompanied by ___, with new ____ ___ formation in the inflamed synovium. Analysis of synovial tissue in RA reveals high levels of ___ and ___. These factors upregulate the production of ____, which are believed to be responsbile for ___ ___.
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Angiogenisis; blood vessel; TNF alpha; IL-1; metalloproteinases; joint destruction
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*Pts often present how? *another key feature *what may precede the onset of joint symptoms?
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*gradual onset of pain and swelling in peripheral joints, usually polyarticular and symmetric
*morning stiffness (>1 hr) *constitutional symptoms like wt loss, fatigue, anorexia |
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WHich 3 joints are most commonly implicated? *what can also be affected? *with what?
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*proximal interphalangeal, metacarpophalangeal, wrist joints *knee joint synovium *resulting in a baker cyst
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Examination of the joints reveals what?
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Inflammatory synovitis (warmth, tenderness, and swelling)
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Late findings include what three joint deformities?
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Ulnar deviation of the phalanges, swan neck, or boutonniere deformities
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Axial joints are less often involved than peripheral joints, but where might you see axial joint findings?
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Cervical spine
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Cervical spine synovial and bursa inflammation can cause ___ ___, a potentially serious complication that can cause ___ ___ ___ with assoicated findings
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*atlantoaxial subluxation *spinal cord compression
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Nodules can be found where? (3) tender or not?
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Extensor surfaces of the forearm and elbow or achilles tendon; not tender
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RA may also be assoicated with? Can be a triad noted as ___ when seen with what?
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Splenomegaly; Felty Syndrome; leukopenia
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RA may also be associated with a severe ____, prsenitng with ___ ___, ___ ___, and ___ ___
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Vasculitis, digital infarcts, palpable purpura, mononeuritis multiplex
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OA presents differently from RA bc of what 2 reasons?
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OA: more distal interphalangeal joint involvement; non-inflammatory
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How does psoriatic arthritis diff from RA?
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Look for psoriasis of the skin and nail changes
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