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Related Flashcards
Cards In This Set
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What does the mesonephros give rise to?
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Functions as an interim kidney in the 1st trimester of fetal life, gives rise to the Wolffian duct of the male genital system, and the caudal end of the mesonephros gives rise to the uteric bud (which becomes ureter, pelvis, calyces and collecting ducts)
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What does the metanephric duct give rise to?
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Glomerulus and renal tubules to the distal convoluted tubule (via interaction with the uteric bud)
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What is the most common site of renal obstruction (hydronephrosis) in the fetus?
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The uteropelvic junction wiht the kidney. It is the last to canalize.
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What is Potter's syndrome? What does it result in?
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Bilateral renal agenesis due to malformation of the ureteric bud. Leads to oligohydramnios, which causes limb deformities, facial deformities, and pulmonary hypoplasia (from increased thoracic pressure).
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A neonate presents with limb deformities, facial deformities pulmonary hypoplasia. Pregnancy was notable for oligohydramnios. What is the disease? What is it caused by?
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Potter's syndrome (bilateral renal agenesis) due to malformation of the ureteric bud.
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Where is a horseshoe kidney most likely located in the abdomen?
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Under the inferior mesenteric artery.
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How do you calculate renal clearance of x?
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Cx = UxV/Px where C is clearance of x, V is the urine flow rate, and P is the plasma concentration of x
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Two equations used to calculate GFR?
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GFR = UinulinV/Pinulin = CinulinGFR = Kf [(PGC-PBS) - (πGC-πBS)]Note: Creatinine clearance can also be used as an approximate measure of GFR
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Effective renal plasma flow?
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UPAHV/PPAH = CPAH
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RBF?
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RPF/(1-Hct)
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Filtration fraction?
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FF = GFR/RPF (normally ~20%)
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Filtered load?
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Filtered load = GFR x plasma concentration
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Where is glucose reabsorbed? Where is PAH secreted?
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Both occur in the proximal tubule.
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How do you calculate the fraction of filtered H2O reabsorbed?
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Fraction of filtered H2O reabsorbed = 1 - 1/[TF/P]
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What does the ratio [TF/Px]/[TF/Pinulin] tell you? What does it correct for?
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It gives you the fraction of the filtered load of a substance remaining at any point along the nephron by correcting for water absorption. With this correction, you can know whether a substance has been reabsorbed, secreted or neither.
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