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Steroid hormones
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4 carbon rings, derive from cholesterol
1. bind to membrane receptors
2. enter cells & activate protein
3. bind to chromosomes, activate/inactiveate certain genes
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Sex limited genes
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Control most diff btw male/female
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Within in brain, sex hormones increase/decrease the rate of...
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Apoptosis-causing certain areas to b slightly larger in males/females
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Y chromosome...
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Alters expression of genes on other chromosomes
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Organizing efffects (sex hormones)
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@ sensitive stage-determine male/female
permanent structural diff to develop gradually
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Activating effects (sex hormones)
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@ any time in life, temporary behavior change, don't last forever, early life=temp
puberty=long lasting change & activing effects
effect lasts longer than hormone remains in organ
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Sex differentiation
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Begins w chromosomes
depends on level of testosterone-sensitive pd 3-4 months of pregnancy
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Prenatal...
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Both male/female have a set of mullerian & wolffian ducts & gonads (testes/ovaries)
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SRY gene
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Sex determining region on male y chromosome, develop into testes
testosterone-causes wolffian ducts to develop seminal vessicles & vas defferens
MIH-hormone causes degeneration of mullerian ducts
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Genetalia
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Develop from 1 biological precursor
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Females lacking estradiol during sensitive pd
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Develop normal parts but not normal sexual behavior, more important for interal anatomy not external
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Absence of sex hormone
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Female!
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Sex hormones
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Bind to receptors in specific areas of hypothalamus & amygdala
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Sexually diamoprhic nucleus
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Anterior hypothalamus, larger in male than females--male sexual behavior
female hypothalamus=cyclic hormone pattern, males cannot do this
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Rodents-testosterone convereted to estradiol to masculizne dvmpt
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Alpha-fetoprotein=in rats, during sensitive pd, not present in adults, binds w estradiol & prevents it from affecting fetus. THis is why females aren;t masculinized by own estradiol
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