+
Related Flashcards
Cards In This Set
| Front | Back |
|
Median age of dx?
|
68
|
|
Higher risk ethnic group?
|
African americans at higher risk of getting it adn dying from it
|
|
Dietary risk factors?
|
Lack of antioxidants, increased fat intake
|
|
Symtpoms?
|
*often asymtpomatic (have high PSA during screening) *localized disease--> obstrucction--> urinary freq, urgency, nocturia (but this can't be distinguished from BPH) *met disease can--> back pain from vertebral involvement
|
|
Phys exam?
|
Prostate often normal or diffusely enlarged...may feel prostate nodule
|
|
Ddx if high PSA? 2
|
BPH, prostatitis (also urinary rettention, transurethral resection of prostate= TURP, and prostate bipsy can elevate psa briefly)
|
|
PSA level that's normal? suggestive of cancer?
|
Normal: <4 ug/mL...suspcious of cancer: >10...between 4-10: 25% of cancer
|
|
Dx how?
|
Transrectal prostate biopsy (use transrectal US) to guide biopsy = definitive diagnosis...take 8-12 samples adn then grade with Gleason score from 1 (well diff)- 5 (poorly diff)...two most common patterns are added together to get a score of 2-10
|
|
Gleason scores divided up how?
|
*2-4 = well-diff *5-6= moderately diff *7= mod-poorly diff *8-10= poorly diff
|
|
15-year mortality for 2-4, 5-6, 7, 8-10?
|
6%, 9, 24, 75% respectively
|
|
TNM staging: T assess how?
|
T: 1= nonpalpable, 2= palpable; T3-4: locally advanced disease
|
|
N: assess how?
|
Regional lymph node involvement: N0 or 1.
|
|
M: assess how?
|
Metastatic disease= M1
|
|
What's recommended for some pts with prostate cancer?
|
Bone scan to look for mets
|
|
3 ways to tx prostate cancer?
|
Surgery, radiation, and/or androgen deprivation therapy
|
