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Most bacterial cell walls contain
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Large complex peptidoglycan molecule
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It consists of
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Long polysaccharide chains
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Made of
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Alternating N-acetylmuramic acid(NAM)and N-acetylglucosamine(NAG) residues
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Pentapeptide chains are attached to
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NAM groups
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Polysaccharide chains are connected through their
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Pentapeptides or by interbridges
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It requires an equally intricate biosynthetic process because synthetic reactions occur both
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Inside and outside the cell membrane
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Two carriers participate
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Uridine diphosphate(UDP) and bactoprenol
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Bactoprenol is a
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55 carbon alcohol
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That attaches NAM by
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Pyrophosphate group
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And moves peptidoglycan through
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Hydrophobic membrane
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The synthesis of peptidoglycan occurs in
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8 stages
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1. UDP derivatives of N-acetylmuramic acid and N-acetylglucosamine are synthesized
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In the cytoplasm
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2. Amino acids are subsequently added to UDP-NAM to form
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Pentapeptide chain
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ATP energy is used to make
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Peptide bonds
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But tRNA and ribosomes are not
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Involved
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