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Cards In This Set
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3 questions of the pharmacist
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1. How do we get drugs to the site of action in the body?2. What effect does the way we get drugs into the body have on the medical condition being treated?3. What can we do to ensure the efficacy of the drug therapy?
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Drug product = ___ and ___
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Active ingredient (drug) and dosage form (vehicle)
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Do not administer a ___ to the patient, but do administer a ___
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Drug; drug product
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A system designed to deliver a well-defined amount of medicinal agent to a known location in the body at a predetermined time and in such a way as to maximize therapeutic effect and minimize side effects (minimize, not eliminate)
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Dosage form
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Drug goes into solution and is absorbed through biomembranes into the body; usually into blood
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Absorption
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Once in the blood, the drug is spread throughout the body; can accumulate in various organs
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Distribution
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Once in the blood, drug structure can be changed by enzymes
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Metabolism
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Drug is removed from the body, primarily via urine or feces
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Excretion
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The sum of metabolism and excretion
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Elimination
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A.D.M.E.
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Absorption, distribution, metabolism, and elimination
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___ and ___ are intimately linked
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Pharmacokinetics and dosage forms
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Want as long as time as possible (for drugs) in the ____
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Therapeutic window
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Highest concentration achieved
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Cmax
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Time necessary to attain peak concentration in blood
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Time to peak
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Fraction (or percent) of dose that is found in blood; use area under the curve (AUC) as measure
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Percent dose absorbed
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