Pharmacy 241

The science of drug action on bioloical systems. Includes two disciplines: Pharmacokinetics and pharmacodynamics.

The quantitative study of: Absorption, distribution, metabolism , and excretion

The study of the effect (molecular, cellular, or biochemical) of drugs and their mechanism of action.

The volume of body fluid cleared of drug per unit time.

The sum of drug clearances by all routes of elimination (e.g. liver, kidney, lung, etc.)

A proportionality constant that relates the dose of drug administration to the plasma concentration

The time required for plasma drug concentration to decrease by 50%

F = Fraction of dose that reaches the systemic circulation following administration of any form

C_Pss = The peak drug plasma concentration at steady state

The minimum drug plasma concentration which can elicit toxic effects

The minimum drug plasma concentration needed to elicit its effect

A.K.A Therapeutic Window... the range of drug plasma levels between the minimum toxic concentration and minimum effective concentration

The minimum toxic concentration divided by the minimum effective concentration

Also known as the alpha phase, it is the portion of a plasma concentration-time curve after a single IV dose which represents movement of drug molecules across the membrane.

Also known as the beta phase, it is the portion of a plasma concentration-time curve after a single IV dose which represents gradual decrease in drug concentration due to metabolism and excretion.