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What is a short acting Adrenergic agonist: Bronchodilator?
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Albuterol (Proventil)
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What is a long acting Adrenergic agonist: Bronchodilator?
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Salmeterol (Serevent)
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What is a non-selective agent Adrenergic Agonist: Bronchodilator?
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Epinephrine (Adrenaline)
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What are the adverse effects for adrenergic agonist bronchodilators?
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Tremors, tachycardia, palpitations, muscle cramps, increased blood glucose
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What are the cautions for adrenergic agonist bronchodilators?
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CV disease, Diabetes Mellitus, HTN, Glaucoma
Pt's receiving MAOI's, Tricyclic Antidepressants, Antihistamines, Levothyroxine (Thyroid Hormone)
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What are the most significant adverse reactions from Epinephrine?
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1. rigidity and tremors in pt's with Parkinson's
2. hyperglycemia (inhibits insulin release in pancreas
3. syncope and LOC
4. repeated injections=vascular necrosis
5. oral inhalation=bronchial irritation and edema
6. rebound bronchospasm
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What are the drug interactions with epinephrine?
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Tricyclic Antidepressants - increase effects
Propanolol and Beta Blockers - excessive hypertension, decreased bronchodilation
Methyldopa - decreased antihypertensive effect
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What is Rhinitis?
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Inflammation of the nasal mucosa
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What are the preventors (prophylaxis) of rhinitis?
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Antihistamines, intranasal glucocorticoids, mast cell stabilizers
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What are the relievers of rhinitis? (immediate, temporary relief)
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Oral and intranasal decongestants (sympathomimetics)
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What is the #1 drug class for prevening rhinitis symptoms?
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Antihistamines
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What are the H1 receptor antagonist/ antihistamines action?
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They block the histamine already released from reaching the receptor sites
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When is the best time to administer loratidine (Claritin)
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Most effective given on an empty stomach (1 hr ac or 2 hrs pc)
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What class is fluticasone (Flonase, Flovent) in?
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Intranasal Glucocorticoids
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Glucocorticoids are used for _____________ (prophylaxis or immediate) relief of perennial allergic rhinitis?
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Prophylaxis. Glucocoritcoids, like fluticasone (Flonase) take 2-3 weeks to take effect.
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