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Hyporeactivity that occurs from chronic
overexposure to a drug (eg- opioid or
alcohol)
a) therapeutics
b) pharmacodynamic tolerance
c) cross tolerance
e) idiosyncrasy
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B) pharmocodynamic tolerance
this is attributed to neuronal adaptation or
cellular tolerance
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A patient is tolerant of morphine and is
likely to display a tolerance to demerol. This is an example of:
a) pharmacodynamic tolerance
b) cross tolerance
c) enzyme induction
this is an example of what?
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B) cross tolerance -
tolerance developed btwn drugs w/in the
same class or different classes that
produce similar pharmacologic effects.
another example is alcohol and inhaled
anesthetics
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In regards to metabolic tolerance -
a decreased response to a dose of a drug may also develop because of...
a) a decrease in the rate of elimination of the drug.
b) an increase in the rate of elimination of the drug.
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B) an increase in the rate of elimination of the drug.
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Drugs that increase elimination or metabolism of itself
a) enzyme inducer
b) enzyme inhibitor
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A) enzyme inducer
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Metabolic tolerance according to Lehne is defined as decreased response to a dose of a drug may also develop because of an increase in rate of elimination of the drug.
this is termed:
a) enzyme inhibtion
b) enzyme induction
c) down regulation
d) up regulation
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B) enzyme induction
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Your elderly patient with COPD uses Salmeterol 2 puffs Q 12 hrs. It appears his response to albuterol inhalations for acute attacks of bronchospasm is less than before he started using salmeterol. This tolerance is often called:
a) pharmacodynamic tolerance
b) up regulation
c) down regulation
d) tachyphylaxis
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C) down regulation
A reason for a need in increased dose is a decreased number or sensitivity of receptor sites after continued dosing.
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In response to constant depression of receptors (as with beta blockers), the body may either increase the number of receptors or increase the sensitivity of receptors
is termed:
a) cross tolerance
b) up regulation
c) down regulation
d) tachphylaxis
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C) up regulation
1 of the reasons why some drugs need to be dc'd slowly
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A rapid tolerance to the effect of some drugs (brought on by repeated dosing over a short pd of time)
a) cross tolerance
b) up regulation
c) down regulation
d) tachyphylaxis
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D) tachyphylaxis
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Describes an unusual effect of a drug
usually occurs in very small % of pts, and may not be related to the dose of the drug
a) adverse reaction
b) side effect
c) idiosyncrasy
d) toxic effect
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C) idiosyncrasy
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Any action of the drug other than the desired therapeutic effect
a) adverse reaction
b) side effect
c) idiosyncrasy
d) toxic effect
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B) side effect
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A noxious, unintended, and indesirable effect that occurs at normal drug doses
a) adverse reaction
b) side effect
c) idiosyncrasy
d) toxic effect
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A) adverse effect
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Effect (usually unexpected) that is produced by large doses of the drug.
a) adverse reaction
b) side effect
c) idiosyncrasy
d) toxic effect
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D) toxic effect
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On prescriptions, is it ok to write Refill PRN?
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No
it is interpreted different ways
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What 5 things should appear in the heading of a prescription?
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Prescriber's name, professional degree, address, office #, and date writtn
it may also include the DEA #
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On the prescription the pt id should include
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Name address and occasionally age if very young or old.
allergies may be included here
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