+
Related Flashcards
Cards In This Set
| Front | Back |
|
Sympathomimetic drugs cause what?
|
Cause the effects you'd get if the SNS was stimulated. (one or more effects of epinephrine or norepinephrine
|
|
Another name for Sympathomimetic drugs
|
Adrenergic agonists
|
|
Three main types of adrenergic agonists
|
Direct-acting adrenergic agonists
Mixed-acting agonists indirect-acting agonists |
|
Norepinephrine is made and released from what?
|
Post- ganglionic
sympathetic nerves except the majority of those
that innervate sweat glands
|
|
Where is NE synthesized?
|
Within the adrenergic nerve endings
|
|
What does NE act on?
|
Adrenergic receptors on smooth muscle, cardiac muscle and glands
|
|
What is the main process that terminates the action of NE
|
Re-uptake, which is accomplished by pumps located in the nerve cell membrane
|
|
Some NE is dergraded in the synaptic cleft by what?
|
COMT
|
|
What can some of the NE be restored in?
|
Granules, then re-released/re-used
|
|
NE can be metabolized by what?
|
Momoamine oxidase (MAO)
|
|
How does an momoamine oxidase (MAO) inhibitors effect the amount of NE in the nerve endings?
|
When it is inhibited the amount of NE in the nerve ending increases because NE is not being metabolized by MAO
|
|
Momoamine oxidase (MAO) inhibitor drugs
|
Phenelezine, Tranylcypromine
|
|
How do tricyclic antidepressants work
|
Decrease CNS neuronal reuptake of NE
|
|
Direct-acting sympathomimetics
|
Act directly on one or more of the adrenergic receptors (alpha and beta)
|
|
Direct-acting sympathomimetics B-2 selectivity
|
Act mainly on only one subtype of adrenergic receptor.
Beta 1 or Beta 2 |
