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Cards In This Set
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What two factors control renin release?Which cells release renin?
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Perfusion pressure and Na+juxtaglomerular cells
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What happens if there is too much Na+ in the blood?
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Na goes through distal tubule where the macula densa cells sense how much Na has gone through. This info is sent via adenosine or prostaglandins to juxtaglomerular cells which inhibit the release of renin. This leads to less filtration of Na.
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What happens if there is too much perfusion pressure?
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Perfusion pressure determines the diameter of juxtaglomerular cells. When there is too much pressure, j cells inhibit release of renin. This blood is filtered back into the body.
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What does angiotensin II do to renin?
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Inhibits renin release - negative feedback
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What does K+ do to renin?
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Regulates renin release
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Does activating Beta cells increase or decrease the secretion of renin?
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Increase!
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What does renin do?
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Changes angiotensinogen to angiotensin I; part of the RAAS pathway that eventually leads to constriction of precapillary arterioles via IP3 and cell growth via DAG, also release of aldosterone
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Where is aldosterone synthesized?How?
What does aldosterone do? |
Zona glomerulosa of the adrenal cortexAngII binds to AT1 receptors which start the synthesis
Up Na reabsorptionUp K excretion |
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What does AngII do at the proximal convoluted tubule?
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Up Na, Cl, and bicarb reabsorptionby stimulating the Na/H exchange pump (so more H excretion)
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What four things does AngII do to increase blood pressure?
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1. Raise sympathetic system2. vasoconstriction of pre-capillary arterioles in skin, splanchic region, and kidneys3. increases heart contractility4. increases ADH release which increases thirst
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True or false: AngIi activates the vagus nerve.
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True. This decreases heart rate reflexively.
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True or false: It takes weeks for ARBs to show their effects.
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True.
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Losartan:
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Short half life but active metabolite (EXP-3174) which is more potent
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Valsartan:
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ProdrugAffected by food
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Irbestartan:
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Like Valsartan but not prodrug and no food effect
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