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Cards In This Set
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What are the selective beta blockers?
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Propranolol, Timolol, Pindolol, Metoprolol, Atenolol, and Sotalol
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What are the nonselective beta blockers?
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Labetolol, Carvedilol
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Which drug is a partial antagonist (has some intrinsic sympathomimetic activity)?
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Pindolol
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Which drugs are cardioselective (don't block beta-2)? Should they be used for asthmatics?
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Atenolol and Metoprolol; no.
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Which drug is best for not giving nightmares? And why?
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Atenolol because it is the least lipid soluble so has the most difficulty penetrating the BBB.
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Which drug will most likely give you vivid nightmares?
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Propranolol
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Which drug blocks Na+ channels the best? Which drugs also block Na+ channels?
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Propranolol; Metoprolol and Pindolol; These drugs should be used for less exciteability
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Beta blocker effects on the heart:
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Decreased heart rate, contractile force, and outputDecreased automaticity, conduction velocity, and myocardial O2 consumptionDirect myocardial depressionAnti-arrhythmic action
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Beta blocker effects on the vasculature:
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Reduced resistanceFall in blood pressure (because of lots of renin and cardiac output)
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Beta blocker effects on the respiratory system:
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Bronchoconstriction and blocked bronchial relaxation
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Beta blocker effects on the smooth muscle:
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More motility and tone
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Beta blocker metabolic effects:
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Inhibition of glycogenolysisInhibition of insulin secretionBlock fatty acid release
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Beta blocker CNS effects:
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Treats anxiety (which causes excitability in parts of the heart)
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What is the body's most powerful vasoconstrictor?
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Angiotensin II
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The renin to aldosterone pathway that beta antagonists block:
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Angiotensinogen to angiotensin 1 via renin.Angiotensin 1 to angiotensin 2 via ACEAngiotensin stimulates aldosteroneAldosterone resorbs Na+ and waterIncreased blood pressure
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