Patho Exam 4 Hematology

Causes of macrocytic anemia

Megaloblastic anemia

Microcytic

Any type of anemia early in its course acute blood loss

Cause of Anemia

Primarily hypovolemia -hemodilution and dec. HCT left shift in neutrophilia (2-5hrs) normocytic, normochromic anemia -HB/HCT fall late (2-3days) erythropoietin due to hypoxi of JG cells internal or external bleeding

GI or GU origin anemia occurs when rate of loss exceeds regenerative capacity of marrow &/or iron stores are depleted anemia due to iron deficiency HB & HCT normal or mildly decreased reticulocyte count normal/increased

Impairs heme synthesis--> hypochromic, microcytic anemia Due to: dietary lack of ____ -impaired absorption -increased requirement -chronic blood loss Most common cause in western world: adult men and postmenopausal women due to GI blood loss

Iron is stored where? stored as?

Measures the iron bound to the globulin transferrin

Reflects stored iron

The major iron binding protein in the blood increases in pregnancy and estrogen in iron overload, ____ may decrease

Iron losses from

High platelet count

Serum iron is decreased TIBC increases % saturation <15% serum ferritin decreases