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Postpartum Hemorrhage Meds
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Ergonovive maleate (Ergotrate, Ergometrine)
methylergonoine maleate (Methergine)
Prostaglandins (carboprost tromethamine, Hemabate)
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Methylergonoine maleate (Methergine)
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PP hemorrhage
continuous uterine stimulation
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Prostaglandins
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Carboprost tromethamine, Hemabate
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Hemabate
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PP hemorrhage, given intrauterine
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Stop preterm labor (tocolytics)
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Magnesium sulfate
Ritodrine
Terbutaline (Brethine)
Nifedipine (Procardia, Adalat)
Indomethacin
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Magnesium Sulfate
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Used to stop preterm labor, CNS depressant; relaxes smooth muscle, used in preeclamptic patients to prevent seizure.
AE: depressed respirations, decreased DTR's, hypotension, extreme muscle weakness, flushing, decreased urine output, pulm edema, serum mag levels >9
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Aquamephyton
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Vitamin K; in newborns to increased production of prothrombin
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Magnesium sulfate antidote
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Calcium gluconate
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Ritodrine
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Used to stop preterm labor; B-adrenergic agonist; relaxes smooth muscle
AE: SOB, coughing, tachypnea, pulm edema, tachycardia, palpitations, chest pain, hypotension, fluid retention and decreased urine production, tremors, dizziness, headache
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Terbutaline (Brethine)
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Used to stop preterm labor; B-adrenergic agonist; relaxes smooth muscle
AE: SOB, coughing, tachypnea, pulm edema, tachycardia, palpitations, chest pain, hypotension, fluid retention and decreased urine production, tremors, dizziness, headache
similar to Ritodrine, but less severe
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Nifedipine (Procardia, Adalat)
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Used to stop preterm labor; Ca channel blocker, relaxes smooth muscle
AE: transient tachycardia, palpitations, hypotension, dizziness, headache
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Indomethacin
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Used to stop preterm labor; prostaglandin inhibitor relaxes smooth muscle
AE: Maternal: NV
Fetal: premature closure of ductus arteriosus
Used only when other methods fail- need 32 wks gestation
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