Front | Back |
30-Day mortality of acute MI?
|
5-10%
|
Spont ____ and ___ of a coronary atherosclerotic plaque may occur, exposing a highly ___ surface. ___ ___ and ___ ___ follow, and the pt clinically presents with an ___ ___ ___
|
Fissure and rupturing; thrombogenic; platelet aggregation adn fibrin formation; acute coronary syndrome
|
What if thrombus--> complete occlusion? what if this is untreated? pathologic Q waves indicate what?
|
*get ST-elevation MI= STEMI *if untreated, get necrosis of myocardium *that necrosis occured throughout the entire thickness of the affected myocardium (doesn't always happen)
|
Get NSTEMI when?
|
Acute coronary syndromes with ischemic chest pain adn elevated biochem markers of myocaridal injury but no classic diagnostic ST elevation on ECG (NSTEMI)
|
In NSTEMI, path Q waves present?
|
NO
|
Conditon that's similar to NSTEMI? how are they diff?
|
*unstable angina (transient thrombus adn occlusion) *no markers of infarction in unstable angina
|
Other than acute mi, mechs for which coronary blood flow or o2 supply or both can be acutely compromised--> mocardial ischemia and infarct?
|
*demand ishcemia (tachycardia, hypotension and/or severe hypoxia in setting of existing fixed CAD)
*coronary artery dissection (often in setting of dissecting aortic aneurysm *coronary vasospasm (idiopathic Prinzmetal angina or drug-induced, eg: cocaine) *in situ thrombus formation (in the setting of a hypercoag state) *coronary embolism *vasculitis (eg: Kawasaki disease) *CO poisoning |
Complications that can lead to death within 1 month from AMI?
|
*arrythmias (v fib/tachycardia, complete heart block) *heart failure (cardiogenic shock) *ventricular rupture (peak incidence within 3-5 days of AMI) *other mech complications (vnetricular septal defecta, mitral papillary rupture)
|
Death occuring >1 month after an AMI can be caused by what?
|
Reinfarction, progressive heart failure, or sudden arrhythmia
|
Pain symtpom in AMI?
|
Retrosternal chest pain, often starting at rest
|
Timing of pain in AMI?
|
Reaches a max over several min and then is prolonged and persistent
|
Radiation of AMI pain? how does nitrate affect pain?
|
*back, neck, arms, or jaw *may provide some relief but generally doesn't resolve the pain
|
Other symtpoms in AMI
|
Diaphoresis, dyspnea, nausea/vomiting, anxiety
|
Unstable angina may present in what ways/
|
Rest pain, new-onset exertional pain, or increasing severity or frequence of established angina
|
Atypical presentations of ami?
|
*pleuritic or sharp chest pain (10-20%) *elderly (esp ihave dementia), diabetics, post-op pts on analgesics: may not give hx of chest pain * instead have fatigue, nausea, syncope, sob
|