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Cards In This Set
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What are CRP level ordered for?
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C-reactive protien, ordered to see if significant levels of inflammation are present
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Process by which antibodies bind to particulate antigens or cells such as bacteria?
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Agglutination
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Visualy what does agglutination look like?
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Clumping of cells
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What does Passive Agglutination (indirect agglutination) utilize to make reaction visible?
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Bead of latex or other materials and are widely used due to their flexibilty, speed and ease of use
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What happens when the antigen has attached to the beads?
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They will agglutinate if the appropriate antibody is in the patient's serum
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What happens when the antibody has been attached to the beads?
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They will agglutinate if the target antigen is present in the patient's sample
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A serum protein (in a class known as acute-phase proteins) that is elevated in inflammatory conditions such as bacterial infections and rheumatoid arthritis?
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CRP or C-reactive protein
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CRP levels tend to decrease or increase before rises in antibody titer and ESR?
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Increase
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CRP levels drop or rise faster than ESR when inflammation subsides?
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Drop
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CRP can determine what 2 things?
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How well treatment is working, also indicates risk of cardiovascular disease
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What latex agglutination slide test reagent did we use for this test?
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Latex Beads that are coated with antibodies against human CRP
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When a serum specimen containing CRP is mixed with the latex reagent, binding to CRP, what will occur?
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Binding of CRP to the beads will occur resulting in visible agglutination of the latex beads
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If the specimen is negative for CRP what will result?
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No Agglutination (a uniformly turbid suspension)
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What size drops did we use?
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Small, lg ones interfere with the reaction
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Where did we place the drops on the slide?
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Off center so that we put the latex reagent drop next to them rather then on top of them
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