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What is innate immunity?
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*Universal to populations
*Non-specific
*Predominate in early stages
*takes only hours for max effect
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What innate immunity cells?
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*neutrophils *monocytes *macrophages
*NK cells * Eosinophils
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What is adaptative immunity?
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*Predominate in the middle and late stages;No physical barriers;Improves during the course of the immune response;Takes days to weeks for max effect.
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What cells are adaptative immunity?
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B and T lymphoctyes
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What are the four main functions of the complement system in the immune response?
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1.Lyse cells, bacteria, and viruses via membrane attack complex (MHC)
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What are the four main functions of the complement system in the immune response?
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2.Opsonization (coating) of foreign cells, bacteria, viruses, fungi, etc. for phagoctyes
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What are the four main functions of the complement system in the immune response?
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3. Generation of peptide fragments (C3a, C5a) to attract leukocytes to sites of infection (chemotaxis)
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What are the four main functions of the complement system in the immune response?
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4.Clearance of immune complexes from the circulation.
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What activates the classic pathway of the complement system?
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Activated by antigen-antibody complexes(IgM, IgG)
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What activates the alternative pathway of the complement system?
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Activated by bacteria, yeast, parasites, virally infected cells or soluble immune complexes (not antibody mediated)
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What activates the lectin pathway of the complement system?
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Acute phase reactants that bind to bacteria. Proteins that recognize and bind to specific carbohydrate target.
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What is the C-reactive protein (CRP)?
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A major acute-phase protein made by the liver for tissue damage that binds to C-polysaccharide cell wall component found on a var of bact and fungi.
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What is Mannose Binding Lectin (MBL)?
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Binds to mannose residues on gylcoproteins or carbohydrates on the surface of bacteria and fungi then activates complement system.
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What do all pathways of the complement system try to do?
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They all try to activate and produce C3b to the activator or pathogen.
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What is a clinical consequence of complement deficiencies?
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If someone is deficient in C3, this would increase the chance of death.
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