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Immune system
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Composed of widely distributed cells, tissues, and organs that recognize foreign substances, including mircroorganisms, and act to neutralize or destroy them
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Nonspecific immune response, nonspecific resistance, innate or natural immunity
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First line of defense against any microorganism or foreign material encountered by the vertebrate host
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Specific immune response, acquired, adaptive, or specific immunity
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Resists a particular foreign agent
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Antigens
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Substances that are recognized as foreign and provoke immune responses
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Antibodies
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Bind to specific antigens and inactivate them or contribute to their elimination
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White blood cells
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Cells that function in both innate and adaptive immunity
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Hematopoesis
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Blood cell development in the bone marrow
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Keratinocytes
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Thick, closely packed cells that make up the outer layer of skin and produce keratin
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Lactoferrin
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Released by activated phagocytic cells called macrophages and polymorphonuclear leukocytes. It sequesters iron from the plasma, reducing the amount of iron available to microbes
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Lactoperoxidase
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An enzyme that catalyzes the production of superoxide radicals, a reactive oxygen intermediate that is toxic to many microorganisms
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Mucociliary blanket
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Coats the mucosal surfaces of lower portions of the respiratory tract and traps microbes
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Alveolar macrophages
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Population of fixed phagocytic cells in the aveoli that can ingest and kill most bacteria
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Paneth cells
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Cells in the mucous membranes of the intestinal tract that produce lysozyme and cryptins
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Cryptins
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A type of defensin that is toxic to some bacteria
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Cathelicidin
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A peptide that arises froma precursor protein having a C terminus bearing the mature peptide of some 12 to 80 amino acids
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