Microbiology Chapter 32

Nonspecific Host Resistance

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Immune system
Composed of widely distributed cells, tissues, and organs that recognize foreign substances, including mircroorganisms, and act to neutralize or destroy them
Nonspecific immune response, nonspecific resistance, innate or natural immunity
First line of defense against any microorganism or foreign material encountered by the vertebrate host
Specific immune response, acquired, adaptive, or specific immunity
Resists a particular foreign agent
Antigens
Substances that are recognized as foreign and provoke immune responses
Antibodies
Bind to specific antigens and inactivate them or contribute to their elimination
White blood cells
Cells that function in both innate and adaptive immunity
Hematopoesis
Blood cell development in the bone marrow
Keratinocytes
Thick, closely packed cells that make up the outer layer of skin and produce keratin
Lactoferrin
Released by activated phagocytic cells called macrophages and polymorphonuclear leukocytes. It sequesters iron from the plasma, reducing the amount of iron available to microbes
Lactoperoxidase
An enzyme that catalyzes the production of superoxide radicals, a reactive oxygen intermediate that is toxic to many microorganisms
Mucociliary blanket
Coats the mucosal surfaces of lower portions of the respiratory tract and traps microbes
Alveolar macrophages
Population of fixed phagocytic cells in the aveoli that can ingest and kill most bacteria
Paneth cells
Cells in the mucous membranes of the intestinal tract that produce lysozyme and cryptins
Cryptins
A type of defensin that is toxic to some bacteria
Cathelicidin
A peptide that arises froma precursor protein having a C terminus bearing the mature peptide of some 12 to 80 amino acids