Microbiology Ch. 13

Regulation of Gene Expression

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Housekeeping genes
Genes that encode enzymes that catalyze reactions that are needed almost all the time
Constitutive genes
Genes that are expressed continuously
Inducer
Molecule that stimulates the transcription of an inducible gene either by binding and inactivating a repressor protein or by binding and activating an activator protein
Inducible genes
A gene whose expression can be increased by either positive or negative transcriptional control
Repressible genes
A gene whose level of expression can be decreased either by negative or positive transcriptional control
Negative transcriptional control
Occurs when the binding of the protein to DNA inhibits initiation of transcription
Repressor proteins
Proteins that practice negative transcriptional control
Positive transcription control
Occurs when the binding of the protein to DNA promotes transcription initiation
Activator proteins
Proteins that carry out positive transcription control
Operator
Region downstream of the promoter where repressor and proteins bind
Activator binding sites
Sites upstream of the promoter where activator proteins bind
Operon
Sequence of bases coding for one or more polypeptides, together with the promoter and operator or activator binding sites
Two component signal transduction systems
Systems that link events occurring outside the cell to gene expression inside the cell
Sensor kinase protein
Spans the cytoplasmic membrane so that part of it is exposed to the extracellular environment while another is exposed to the cytoplasm
Response-regulator protein
DNA binding protein that when activated by the sensor kinase, can act as either an activator or a repressor