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Pathogenicity
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Ability to cause disease
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Virulence
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Extent of pathogenicity
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Portals of Entry - Organisms in the body
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Mucous membranes
Skin Parenteral route |
Parenteral route
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Injection or bloodstream via a vector
|
Skin
|
Infection or burrowing of a parasite
|
Mucous membranes are found
|
In openings of body
|
Preferred portal of entry
|
Most likely place to cause disease
|
Invading Microbes ID50
|
Infectious dose for 50% of test group
Higher ID50- least likely to become sick |
Invading Microbes LD50
|
Lethal Dose for 50% of test population
Higher LD50- least likely to die fro pathogen |
Adhesins
|
Binds to receptors on host cells
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Ligands
|
Binds to receptors on host cells
|
Virulence Factors
|
Adherence ,capsules, cell walls, enzymes
|
Cell Wall Virulence Factor - M protein
|
Resist phagocytosis And Adherence
streptococcus pyogenes |
Cell wall virulence factor- Opa protein
|
Inhibits T-helper cells
Neisseria gonorrhoea |
Cell Wall virulence factor- Mycolic acid
|
Resists digestion of cell wall
Mycobacterium tuberculosis |