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Cards In This Set
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GPCR architecture
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Seven membrane spanning alpha helixes
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G - proteins
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1) guanine nucleotide binding proteins 2) central element for signal transduction between receptors and effectors3) anchored to the cytoplasmic face of the membrane
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G - protein heterotrimer consists of:
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A guanine nucleotide binding alpha subunita beta subunita gamma subunit
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Which subunit is closely associated with the gamma subunit?
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The beta subunit
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Which subunit is primarily hydrophilic?
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The alpha subunit
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GPCR family 1 is
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Aka family A or the rhodopsin-like family
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GPCR family 1 contains receptors for?
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Odorants, small molecules (catecholamines and amines), some peptides, and glycoproteins
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In GPCR family 1, what connects the first and second extracellular loops (ECLs)?
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Highly conserved residues and a disulfide bridge
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GPCRs in family 1 have what in their carboxyl terminal tail?
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Palmitoylated cysteine
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GPCR family 2 is characterized by
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Long amino terminus w/ several cysteines that form a network of disulfide bridges.
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GPCR family 2 ligands
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Hormones - glucagon, gonadotrophin releasing hormone, and parathyroid hormone
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The connection between ECL1 and ECL2 in GPCR family 2 is
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A disulfide bridge w/o the palmitoylation site
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GPCR family 3 contains
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Metabotropic glutamate, the Ca2+ - sensing, and gamma-aminobutyric acid (GABA) receptors
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Family 3 GCPRs are characterized by
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A long amino terminus and carboxyl tail
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What is described as a "venus fly trap"
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The ligand binding domain on the amino terminus (GPCRs family 3)
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