+
Related Flashcards
Related Topics
Cards In This Set
| Front | Back |
|
Fixed Acids?
|
CH3(CH2O)COOHH2SO4,H3PO4
|
|
What acids will be produced in larger amounts under oxygen-limited (hypoxic) conditions?
|
Lactic Acidβ-hydroxybutyric acidacetoacetic acid
|
|
What acids can the body neutralize without kidney function?
|
Acetoacetic acid (via acetone and CO2 after decarboxylation)carbonic acid
both through the lungs (voatile) |
|
Which acids do the kidney neutralize?
|
Fixed/Metabolic acids:acetoacetic acidβ-hydroxybutyric acidLactic Acid
|
|
Ketoacidosis can occur from accumulation of what?
|
Ketone bodiesβ-hydroxybutyric acidacetoacetic acid
|
|
Uncontrolled diabetes mellitus can be accompanied by what?
|
-ketoacidosis-displacement of K+ from the cytoplasmic compartment-erosion of tooth and bone-cardiac arrhythmia
|
|
What imposes an acidic load?
|
NH4ClMgCl
|
|
What imposes an alkalai load?
|
NaHCO3AlOH3
|
|
What will cause acidosis?
|
Respiratory: high PACO2metabolic: low PACO2
|
|
What will cause alkalosis?
|
Respiratory: low PACO2
|
|
Raising PP of CO2 to 60 mmHg causes the blood to do what?
|
-contain 0.03 mM CO2 for each mm Hg of alveolar Pco2
-contain 1.8 mM CO2 (0.03 x 60mm Hg) -HCO3: CO2 = 24/1.8 = 13.3 -pH = 6.1 +log [HCO3-]/(0.3 x PCO2) = 7.22 |
|
Cori Cycle inhibition would do what to lactate?
|
Lactate degradation would not occur (increase in lactate)
|
|
How many forms does PFK come in?
|
2, PFK-1 and PFK-2both can be affected by pH
|
|
What would inhibition of PFK-1 by H+ cause?
|
A decrease in glycolytic throughput
|
|
What would inhibition of PFK-2 by H+ cause?
|
-a decrease in glycolytic throughput-an inhibition of PFK-1 by allosteric mechanism
|
