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Cards In This Set
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What is the difference in structure b/t the innate and adaptive immune system?
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Innate: PAMPs
Adaptive: antigens
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What has greater diversity--adaptive or innate?
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Adaptive
The innate receptors are encoded in the germline and very limited
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What branch of the immune system is able to distinguish self from non-self?
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Adaptive AND innate
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What are two characteristics of structures recognized by the innate immune system?
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1. Not variable
2. Important for function of microbe
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What are 5 epithelial barriers to bacteria?
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1. Epithelium intact
2. Defensin (protein antibiotic made by skin
3. Intraepithelial lymphocytes in dermis
4. Mast cells covered with FcR (bind Fc of AB)
5. Normal flora--competition
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When do monocytes mature into macrophages?
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When they move from the blood to the tissue
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What cellular feature would show a macrophage has matured?
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The nucleus goes from a big C shape to a small nucleus
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What do damaged endothelial cells secrete?
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Chemokines
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What is the function of chemokines?
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They bind endothelial cells and increase expression of adhesion molecules
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What is the first adhesion molecule expressed by an endothelial cell? What does it recruit?
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1. E-selectin
2. Neutrophils
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What is the 2nd adhesion molecule expressed?
What does it recruit?
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1. I-CAM1
2. Monocytes
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What is the 3rd adhesion molecule expressed?
What does it recruit?
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1. V-CAM1
2. T cells
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How long does it take for the adaptive immune system to enter damaged tissue?
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~24 hrs (when VCAM-1 recruits T cells)
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Leukocyte is...
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All WBCs
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Lymphocytes are..
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T, B, NK cells
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