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MHCs products are involved in: ________ and _________
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Intracellular recognition and self. vs. non-self discrimination.
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MHC is an ___________________ structure.
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Antigen-presenting
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MHC in humans =
MHC in mice =
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HLA
H-2
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Class I MHC
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Genes encode glycoproteins present on the surface of nucleated cells and presents antigens to CD8 T cells.
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Class II MHC
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Genes encode glycoproteins on antigen-presenting cells and present antigen to CD4 T cells
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Class III MHC
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Genes encode many proteins that have immune function, complement components, and mediators of inflammation
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Class I MHC units
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Alpha 2 and 3
alpha 1 and beta 2 microglobulin
in peptide cleft = alpha 2 and 1
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Class II MHC units
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Beta 1 and 2
alpha 1 and 2
in peptide cleft = beta 1 and alpha 1
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MHC class I and II molecules are encoded by conventionally stable genes that ________, _________, _________
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Don't rearrange
don't undergo develoment
don't undergo somatic processes of structural change
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Nonpolymorphic
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Genes represented by only one normal nucleic acid sequence in all members of a species
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Polymorphic
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When alternative forms or variants of a gene are present in a population
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The genetic loci that makes up the MHC is _________
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Highly polymorphic
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Genes for the MHC loci lie _______ and individuals inherit the alleles encoded by these loci as two sets, one from each parent, called__________
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Close together
haplotype
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Alleles are________ in MHC
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Co-dominantly expressed
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________ can be histocompatible with each other but not with ___________
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Siblings
parents
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