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Cards In This Set
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Th-17 effectors
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Inflammatory, promotes neutrophil recruitment
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T-regs
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Suppressive, promotes tolerance, secrete IL-10 or TGF-beta to turn off other cells. Thus other t cells won't attack foreign particles that have been adapted.
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Mucosal Nodes
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Express unique adhesion molecules that promote homing of lymphocytes to mucosal lymph tissues. This allows compartmentalization of mucosal response.
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Vitamin A
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Can be made into transretinoic acid which acts on t cells. Retinoic acid promotes expression of chemokine receptor CCr9 and Integrin alpha-4-beta-7. These promote binding to gut lumen.
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M cells
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Conduits of antigen sampling. They take up antigens and present them to dendritic cells on other side of lumen.
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Lymphoid Organization
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Peyers patches and mesenteric lymph nodes are sites for antigen processing and immune response
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4 mechs T regs suppress effector t cells and DC's
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1. Inhibitory cytokines mon2. Cytolysis mon 3. Metabolic Disruption mon4.Targeting Dendritic cells mon
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Signals disabling T regs function
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IL-6, TLRs, pathogen presence
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