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The primary lymphoid organs, or generative organs, are those in which lymphocytes mature. This includes: 3
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1.) Expression of receptors 2.) Positive and negative selection 3.) Attaining functional and phenotypic maturity
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The major site of hemopoesis before birth
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Fetal liver
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Bone marrow by differentiation of bone marrow stem cells is driven by
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Cytokines
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The 1st stage of cell differentiation is the _____ cell that does not express membrane immunoglobins
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Pro- B cell
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In Pro-B cell (1st stage of cell differentiation) there is gene rearrangement to produce a ____ chain
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U (mu) heavy chain
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In cell differentiation, once the u (mu) heavy chain is actually synthesized, the cell becomes a ______
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Pre-B cell
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The Pre-B cell then produces a _______ receptor
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Pre-B cell receptor
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T or FThe pre-B cells have specific recognition
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FalseThis receptor doesn’t seem to have specific recognition but is thought to be stimulated by self signals that are necessary for survival
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The pre-B cell then rearranges light chain genes (k or gamma) to produce a B cell receptor and becomes an _______ .
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Immature B cell
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The B cell receptor produced by pre-B cells are Ig__ only
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IgM
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Immature B cells that are strongly stimulated by self-antigen at this point either die by apoptosis or are inactivated. This process is
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This is negative selection
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The surviving immature B cells mature, migrate to the _____, express surface IgD (as well as IgM), become competent and populate secondary lymphoid organs
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Spleen
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True When Pre-B cells rearragne light chains (kappa and lambda), the result is 1 kappa and 1 lambda
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False!Always 2 kappa and 2 lambda
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Immature T cells, _______ , leave the bone marrow and migrate to the thymus
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Prothymocytes
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The ______ is a bilobed organ over the heart
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Thymus
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