Front | Back |
Surface Mutation, Hb E
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Glu beta26 to Lys, no effect
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Surface Mutation, Hb S (sickle cell)
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Glu beta6 to Val, blood flow blockage, anemia, cardiac enlargement
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Destabilizing Mutation, Hb Hammersmith
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Phe beta42 to Ser, unstable Hb
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Destabliziing Mutation, Hb Bristol
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Val beta67 to Asp, unstable Hb
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Destabilizing Mutation, Hb Savannah
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Gly beta24 to Val, unstable Hb
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Destablizing Mutation, Hb Bibba
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Leu alpha136 to Pro, unstable Hb
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Destablizing Mutation, Hb Philly
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Tyr alpha35 to Phe, unstable Hb
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Methemoglobin Stable, Hb Boston
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His alpha58 to Tyr, stablizes Fe3+
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Methemoglobin Stable, Hb Milwaukee
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Val beta67 to Glu, stablizes Fe3+
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Change alpha1-beta2 contacts, Hb Yakima
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Asp beta99 to His, increase O2 affinity
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Change alpha1-beta2 contacts, Hb Kansas
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Asn beta102 to Thr, reduced O2 affinity
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