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RBCsmaller than normal --> microcyticincreased zone of central pallor -->hypochromic (less hemoglobin in each RBC) increased aniso + poik
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Microcytic, hypochromicMost common cause: Fe deficChildren + Women (menses, preg)
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Macrocytosishyerperseg neutrophilsee in Megaloblastic anemia (B12/folate)
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Macro-ovalocyteshyperseg~~> PA(compare RBC to lymph @lower left)
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Shistocytes = fragmented RBCseen in IV hemolysistypical finding for DIC
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Center: several HJB (nucl remnant)below: nRBCincreased poik, aniso, + inclusions --> Spleen not present
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Microcyticlack central pallor --> spherocytesHereditary Spherocytosis = lack of spectrin, decreased lifespanTest: increased osmotic fragility
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NRBC + basophilic stippling in cyto--> toxic injury to BM (eg. lead poisoning, megaloblastic anemia)
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Atypical lymphslarger cytonucleoliindented by RBC~~> IM
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Sickle cell anemia in crisisSS prone to crystallization @low O2 tensionAS less likely to be in crisis
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Hgb SCC --> target cellsRectangular RBC = Hb C crystal ==> characteristic of Hb C
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