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Related Flashcards
Cards In This Set
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Fatty acids are synthesized from and oxidized to this compound
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Acetyl-coA
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Where does beta-oxidation of fatty acids occur?
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Mitochondria
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Where does fatty acid biosynthesis occur?
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Cytoplasm
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Protein attached to long chain fatty acids in cells
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Fatty acid binding protein / Z protein
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Long chain fatty acids are usually in free or lipoprotein form?
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Lipoprotein
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Why are short chain and medium chain fatty acids less likely than long chain to be combined with protein?
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They are more water-soluble
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Which step in beta oxidation requires ATP?
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The conversion of long chain fatty acids to fatty acyl-CoA (the active intermediate)
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Is the conversion of long chain fatty acids to fatty acyl-CoA reversible?
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No
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Enyzme responsible for
LCFA --> fatty acyl-CoA
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Acyl-CoA synthetase
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Which vitamin is needed for the action of acyl-CoA?
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Vitamin B5 (panthothenate)
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What is another name for beta-OH-gamma-trimethylammonium butyrate?
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Carnitine
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What is carnitine synthesized from and where?
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Methionine and lysine in the liver and kidney
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Carnitine is widely distributed, especially in....?
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Mitochondrial membranes of muscle tissue
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What must long chain acyl-coA units form in order to penetrate the inner mitochondrial membrane?
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Acylcarnitines
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What is the action of carnitine palmitoyltransferase 1 (CPT-1)? where is it located?
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Converts long chain fatty acyl-CoA units to acylcarnitine - found in the outer mitochondrial membrane
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