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What is another name for anti-freeze toxicity
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Ethylene glycol toxicity
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What products contain ethylene glycol
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Anti-freeze, solvents and film processing solution,
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What is the toxic dose of ethylene glycol for dogs? for cats?
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Dogs- 4-6 ml/kg .........cats- 1.5 ml/kg (6.8ml or 1 tsp is lethal in a 10# cat)
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What does the metabolism of ethylene glycol lead to
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The formation of metabolites that cause acidosis and formation of calcium oxalate crystals and a decrease in the pH
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Why is it bad for the kidneys for an animal to digest ethylene glycol
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The calcium oxalate crystals will precipitate in the renal tubules that will lead to clogging and damage of the renal tubules that lad to renal failure
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What can renal failure due to ethylene glycol lead to
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Anuria
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How many stages of symptoms are there is ethylene glycol (anti-freeze) toxicity
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There are 3 stages (1-neurologic, 2-cardio/resp, 3- renal)
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What are the symptoms you will see in stage 1 of ethylene glycol toxicity
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Neurologic signs such as depression, ataxia (lack of coordination), seizures, coma, death, vomiting, PU/PD (urinate more then drink more)
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How long after digestion of ethylene glycol will you notice stage 1 symptoms
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30 minutes to 12 hours
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What symptoms will you notice in stage 2 ethylene glycol (anti-freeze) toxicity
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Cardio-respiratory symptoms such as tachypnea (rapid breathing) which is caused by the acidosis, and tachycardia (rapid heart rate)
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How long after digestion of ethylene glycol will you notice stage 2 symptoms
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12- 24 hours
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What symptoms will you notice in stage 3 of ethylene glycol (anti-freeze) toxicity
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Renal symptoms such as severe depression, vomiting, dehydration, azotemia, oliguria, anuria and a increased BUN and creatine
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What are the labortory findings you will see in ethylene glycol (anti-freeze) toxicity
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Acidosis, hyperglycemia, increased BUN and Creatinine, calcium oxalate of hppuric acid crystals in urine and a positive in-house ethylene glycol test
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What is the prognosis of ethylene glycol (anti-freeze) toxicity
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Poor if any symptoms are present
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What is the first treatment option for ethylene glycol (anti-freeze) toxicity
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Induce vomiting immediately
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