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Cards In This Set
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Major Events of Homologous Recombination
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 End Resection only a requirement in HR |
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What causes the cell to choose Homologous Recombination?
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Cell in late S and G2 because it requires the sister chromatid nearby to repair and because end resection is regulated by CDK1 which is only present in S and G2
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Major Proteins Invloved in Homologous Recombination
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RecA, Rad51, Rad54, ATM,
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HR pathways
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DSBR:
SDSA: SSA: BIR: RecF: |
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Major Events of Nonhomologous End Joining
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Ku70/80 binds DNA ends. DNA-PK bind to Ku heterodimer and autophosphorylate. XRCC (ligas IV) ligates DNA together
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What causes the cell to choose NHEJ?
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Quick and in all stages of cell cycle. All cells in G0/G1 are repaired by NHEJ. Most NHEJ occurs in G1.
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Major Proteins Involved in NHEJ
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Ku 70/80, XRCC4-Lig4, DNA-PKs
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V(D)J Recombination
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Randomly combines Variable Diverse and Joining Genes in B cells.
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