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CEREBROVASCULAR CNS SYNDROME
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FLUID IN BRAIN
DEATH IN 1-3 YEARS
>10,000 RADS
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GASTROINTESTINAL SYNDROME
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DAMAGE TO CRYPT CELLS
500-1200 RADS
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HEMATOPOITIC SYNDROME
BONE MARROW
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MITOTIC CELLS
200-800 RADS
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LD 50/30 50 % 30 DAYS
450 RADS
ONE EXPOSURE WHOLE BODY
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REPAIR
REPOPULATION
REOXYGENATION
REASSORTMENT (REDISTRIBUTION)
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SENSITIVE IN MITOSIS
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RESISTANT IN LATE S
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STOCHASTIC EFFECTS
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NO THRESHOLD 1 DAY OR 1 YEAR
CANCER
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NON STOCHASTIC (DETERMINISTIC)
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MINIMUM THRESHOLD
CATARACTS, ERYTHEMA
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RADIATION SAFETY GOALS
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ELIMINATE NON STOCHASTIC
REDUCE STOCHASTIC, REDUCE EXPOSURE
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TDF
TIME DOSE FRACTIONATION
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NOMINAL STANDARD DOSE BASED ON SINGLE EXPOSURE TO CONNECTIVE TISSUE
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LINEAR QUADRATIC FORMULISM
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BED- BIOLOGICAL EFFECTIVE DOSE
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ALPHA= DIRECT CELL KILL DBL STRAND BREAK
BETA= INDIRECT CELL KILL, SINGLE STRAND
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ALPHA/ BETA RATIO- COMPARE REGIME
3 GY FOR LATE RESPONDING NORMAL
10 GY FOR EARLY TESPONDING TUMOR
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STANDQUIST CURVES
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BASED ON SKIN TOLERNCE
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TBI KILLS IMUNE SYSTEM
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DOSE NOT REJECT BONE MARROW TRANSPLANT
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LET- LINEAR ENERGY TRANSFER
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HIGHEST FOR CHARGED PARITCLES
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RBE- RELATIVE BIOLOGICAL EFFECTIVENESS
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HIGHEST FOR CHARGED PARTICLES
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