DNA Replication

TATA bok origin of replication

Helicase comes in and separates the two strands by breaking the hydrogen bonds that were holding the nucleotides together. creating the replication fork.

Single stranded binding proteins attach to the dna nucleotides and kept them separated.

In the leading strand an rna primer is placed on the strand by polymerace. the primer tells dna polymerace where to start adding new nucleotides.

Dna finds the rna primer in the leading strand and starts adding new dna nucleotides that are compliments to the parent strand in the 5' to 3' direction towards the replication fork.

Another dna polymerace comes into the leading strand and replaces the rna nucleotides with with dna nucleotides.

Dna ligase then comes in and bonds the DNA molecule back together (cleans it up.)

In the lagging strand replication works backwards away from the replication fork.

Rna primer adds rna nucleotides to tell DNA polymerace where to start.

Dna polymerace then adds new dna nucleotides that compliment the parent strand going from 5' to 3' but moving away from the replication fork.

THEn a primer gets placed closer to the replication fork. and dna polymerace adds new nucleotide compliments again.

In the lagging strand dna replication works from primer to primer in okazaki fragments.

Then the rna is switched with dna just like it was in the leading strand. (Dna polymerace does this.)

Ligase then fills in the gaps and cleans things up.