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Cards In This Set
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What are the main functions of the cytoskeleton? (3)
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-cell scaffolding- shape cells- driving force behind cell movement
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What are the 3 major components of cytoskeletons?
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Intermediate filaments, microtubules, microfilaments
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What is the width of microfilaments?
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7-11nm
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What is the width of microtubules?
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25nm
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What is the width of microfilaments?
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5nm
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Which cytoskeleton component has a coiled coil structure?
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Intermediate filaments
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Explain each of the following with respect to IFs:-composed of____
-stability ____-where they're found ___ |
- fibrous polypeptides in an alpha helical rod (a dimer)- relatively stable- different types are associated with different cells, but they are all specific to that cell
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How can we use microfilaments for research purposes?
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For typing of cells
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Name the 4 types of IFs, the monomers that fall into each of those groups, and where each of those are found.
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 . |
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Explain the structure of IFs
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There are alpha helical dimers, four of which line up to form a tetramer. Tetramers aggregate end-to-end to form a protofilament. 8 protofilaments make a 10nm thick IF. Globular domains project from the surface and account for variations between individual types of intermediate filaments
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Protofilament
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Type of intermediate filament that is composed of 4 intermediate filament dimers (a tetramer).
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The main function of IFs is to ______
-how? |
Maintain cell structure
- they extend from the nuclear envelope to the plasma membrane. Keratin filaments form a network that crisscrosses the interior of the cell and attach to the spot desmosomes. |
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As far as construction of IF goes, there is no evidence for ________
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Rapid polymerization or depolymerization
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IFs are common in what cells?
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- cells subject to mechanical stress, epithelial and cardiac muscle cells
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Microtubules are composed of _____
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Alpha and beta tubulin which form a hollow single microtubule
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