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In a cardiac muscle contraction _________ of the heart is rhythmic and spontaneous
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Depolarization
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What do gap junctions do?
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Ensure the heart contracts as a unit
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In cardiac muscle contraction depolarization opens what?
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Voltage gated Na+ channels in the sarcolemma
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Reversal of membrane potential goes from what to what?
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-90mv to +30 mv
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Depolarization wave in T tubules causes the SR to what?
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Release Ca2+
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In cardiac muscle contraction depolarization wave does what?
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Opens slow Ca2 channels in the sarcolemma
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In cardiac muscle contraction Ca2+ surge does what?
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Prolongs depolarization phase (plateau)
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Depolarization is due to what?
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Na+ influx through fast voltage gated Na+ channels.
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In depolarization a positive feedback cycle rapidly opens many Na+ channels doing what?
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Reversing the membrane potential. channel inactivation ends this phase
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The plateau phase is due to what?
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Ca2+ influx through slow Ca2+
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In the plateau phase the Ca2+ influx through slow Ca2+ channels does what?
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Keeps the cell depolarized because few K+ channels are open for overflow
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Repolarization is due to what?
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Inactivation of Ca2+ channels and opening of K+ channels.
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In repolarization Inactivation of Ca+ channels and opening of K+ channels allows what?
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Allows K+ efflux, which brings the membrane potential back to its resting voltage
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Ca2 influx triggers what?
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Opening of Ca2+ sensitive channels in the SR, which opens up bursts of Ca2+
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Excitation- contracting coupling occurs as Ca2+ binds to tropinin which allows what?
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Actin and myosin filaments to begin sliding past one another
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