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Cards In This Set
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Rituxan-rituximab (monoclonal antibody)Time:varies 1st vs 2nddose or rapid infusionTX:locks onto protein receptor (CD20) found on B lymphocytes (B cells) then brings in other immune cells to kill themUsed for:non Hodgkins lymphoma, rheumatoid athritis, ITPSide effects: allergic reaction with first dose- shaking, chills
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Rates-test dose: 100 mg- 3 hour- Day 1remainder of dose Day 2Cycle 2 Day 1 entire dose, decrease time1st50 mg/hr- increase by 50 mg/hr q 30 minutesMAX 400mg/hr2ndstart at 100mg/hr-increase by 100 mg/hr q 30 minutesMAX 400 mg/hrrate=mL/hrvolume=1/2=1/2 rate RAPID INFUSION- after no reactionex: 750mg/500 mL20% of dose:150 mg for 30 min80% of dose:600 mg for 1 hour
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Oxaliplatin/Eloxatin (alkylating agent)time: 2 hoursGive with D5W only!!!TX:platinum chemo alkylating agent. Stops the growth of cancer cells, which causes them to die
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FOLFOX: given with Leucovorin followed by 5FU (CIV 22 hours)CapOX: oral xeloda (oral 5FU) IV Oxaliplatinalso given aloneSE:decreased blood counts, loss of appetite, nausea, vomiting, numbness, tingling(nerve irritation), numbness of lips, abd pain, mouth sores, fatigue
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Levoleucovorin- (folate analog)time:90 minutes- 2 hourstx: prevent or treat the harmful effects of some medications
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RX: can be given with oxaliplatin or irinotecan or given alone with 5FU. Makes 5FU work better but in combo with 5FU causes diarhea, nausea, mouth sores
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Fluorouracil/5FU- (Antimetabolite)time: varies, IV push, CIV pump (24, 46, 96, 168 HOURS)TX:Antimetabolites are very similar to normal substances within the cell. When the cells incorporate these substances into the cellular metabolism they are unable to divide. Antimetabolites are cell specific, they attack cells at specific phases of the cell cycle.
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SE: diarrhea, nausea, mouth sores, taste changes, low blood changes
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Bleomycin-Blenoxane- IRRITANT (antitumor antibiotic)Time:10 minutes*1st DOSE- test dose 1U SQ upper armTX: stops the groth of cancer cells, which causes the cell to die. Also used to tx cancer in the lungs, to keep fluid btween the lungs and the chest wall.Because of the pulmonary toxicities with increased dose, PFTs and CXR should be obtained as outline by protocol.
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TX:testicular, lymphoma, squamous cell ca of : head, neck , cervix SE: fever, chills, mouth sores, finger and toe nail changes, darkening and thickening of the skin, itching, skin rash, vomiting, loss of appetite, weight lossregimen:ABVD2314
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Cerezyme- imiglucerasetime:1-2 hoursSE"headache, nausea, dizziness
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TX:an enzyme used to replace a deficiency in persons with Gauchers disease
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Cytoxan, cyclophosphamide (alkylating agent)time:30-60 minutes, can be given orallyinfusion reaction- watery eyes, congestion, nasal fullnessTX: helps stop cancer cells from growing, causing them to dieTX:lymphoma, leukemia, multiple myeloma, neuroblastoma, retinoblastoma, mycosis fungoides, breast, ovary
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SE: bladder irritation-encourage hydration, decreased blood counts, nausea vomiting, diarrhea, hair loss, mouth sores RARE- pulmonary toxicity, renal toxicity, infertility
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Dacogen, decitabine (anti metabolite)Time: 1 hourTX: MDSgiven Days 1-5 with neupogen support
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TX: Has a toxic effect on the abnormal effect on the abnomral MDS cells. Promotes normal specialization and blood cell growth so the body can better make WBCs, RBCs and platelets SE: fatigue. fever
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Dacarbazine, DTIC (alkylating agent)time- 90 minutes (peripheral y site NS for comfort irritation of vein) 60 minutes (port)TX: helps to stop cancer cells from growing, causing them to dieTX: metastatic malignant melanoma, Hodgkins disease, soft tissue sarcomas, neuroblastoma, fibrosarcomaABVD2314
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SE:decreased WBC, decreased platelet, nausea, vomiting, hair loss flu-like illness (fatigue, h/a, muscle aches, fever). loss of appetite, irritation of vein
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Xgeva, denosumab (monoclonal antibody)SQ every monthTX outside of the bonebone modifying agent, breaks down causes lysis of osteoclastsprevention of skeletal related events (need for XRT, fx due to ca in bone surgery of bone, spinal cord compression) in pts w/ bone mets from sold tumors
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SE: fatigue, muscle weakness, nausea Can cause hypocalcemia, should be on calcium and vitamin D.Osteonecrosis of the jaw.At risk of fracture after discontiuation.
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Vidaza, azacitidine (antimetabolite)time 30 minutesIV or SQ for 5 daysTX: MDS- disease of the bone marrow
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TX: reduces the growth of cancer cells and can suppress the immune system. Helps the restore normal growth and differention in bone marrow cells
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Velcade, bortezomibTX: multiple myloma, waldenstrom's diseaseInjection 3-5 secondsTX: slows the growth of cancer cells
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SE: increase neuropathy, skin irritation
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Alimta, pemetrexed (antimetabolite)time: 10 minutes every 3 weeksneed B12 injection and daily folate, should continue for at least 3 weeks after last dose, minimize side effects (rash)TX: lung cancer, mesothelioma, head and neck cancer, pancreatic, bladder
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SE: low blood counts, nausea, vomiting, sores in mouth, rash, itching, peeling, diarrhea, constipation, loss of appetite, fatigue, difficulty breathing
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Erbitux, cetuximab (monoclonal antibody)time:1st dose:2 hoursafter 1 hourpremed with antihistimineTX: colorectal, head, neckTX: designed to seek out and lock onto a protein called epidermal growth factor receptor (EGFR) brings in immune cells to help kill them
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SE: very common can be sever, hypersensitivity reaction, fatigue, change in nails, decreased electrollyte levels, fever, weakness, malaiseless common: nausea, vomiting, diarrhea, consitpation
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IVIG, octagam, immunoglobulinuse pumpTX:immunoglobulin for immune deficiency where the body does not make enough antibodies Given for some autoimmune disorders where an abnormal autoantibody is being formed (inactivated by IVIG)
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SE: headache, fatigue, rash, flu-like premed: antihistimine, tylenol, may also need steroidincrease hydration
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