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Cards In This Set
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What do heparin-like molecules do?
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Enhance ATIII activity
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What does ATIII do?
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Neutralizes activated serine protease coagulation factors.Factors XII, XI, IX, and X, and Thrombin
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What does Prostacyclin I2 do?
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Vasodilator, inhibits platelet aggregationsynthesis is not inhibited by aspirin
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What do proteins C and S do?
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Inactivate factors V and VIII, enhance fibrinolysis
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What does tissue plasminogen (tPA) activator do?
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Activates plasminogen to release plasminreleased by endothelial cells
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What are the factors that enhance thrombus formation in small vessel injury?
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Thromboxane A2 (TXA2)Von Willebrand factor (vWF)Tissue thromboplastin (factor III)Extrinsic and intrisic coagulation systems
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What are the functions of thromboxane A2?
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Vasoconstrictor, enhances platelet aggregation
enhances fibrinogen attachment to GpIIb-IIIa receptors |
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What is vWF?
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Platelet adhesion molecule; synthesized in Weibel-Palade bodies in endothelial cellsBinds platelets to exposed collagen via GpIb receptors
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What is factor VIII:c?
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Synthesized in the liver, complexes with vWFDissociates from vWF when activated by thrombin and performs its procoagulant function in the intrinsic coagulation cascade system
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What happens to factor VIII:c when vWF is decreased?
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VIII:c is increasingly degraded... so decreased vWF = decreased VIII:c
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What is tissue thromboplastin (factor III)?
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Activates factor VII in the extrinsic coagulation system, released from injured tissue
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What are the platelet receptors?
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GPIb (binds to vWF)GpIIb-IIIa (binds to fibrinogen)
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What drugs interfere with the GpIIb-IIIa receptor function?
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TiplopidineClopidogrelAbciximab
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What are the important platelet storage proteins?
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ADPvWFfibrinogen
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What are the functions of platelets?
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Stabilizes intercellular adherens junctions in venular endothelial cells
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