+
Related Flashcards
Related Topics
Cards In This Set
| Front | Back |
|
Signal transduction pathways involve what three things
|
Signal
Receptor
Response
|
|
What is the
|
4
|
|
EnvZ
|
The E. Coli receptor protein for changes in solute concentration
|
|
Where is EnvZ located
|
It is a transmembrane protein that extends across the bacteriums plasma memnrane and into the space between the outer membrane.
|
|
What happens when the solute concentration changes between the outer and plasma membrane
|
The change in the aqueai solution causes the part of the protein receptor that sticks out to change in conformtion.
|
 What are the steps in this picture |
1. solute enters space
2. The EnvZ receptor changes shape/catalyzing the addition of a phoshage from ATP
3The phosphate from EnvZ is transfered to the responding OmpR protein
& the OmpR chages shape enabling it to bind to DNA& stimulates transcription of OmpC gene
4. OmpC protein inserts into the outer membranepreventing solute entry
|
|
Domain
|
A sequence of amino acids foled into a particular shape
|
|
Potein Kinase
|
Duh
|
|
E.coli respond to increased solute concentrations by phosphorylation of the membrane receptor _______________, which transfers a phosphate to the subcellular second messenger ______________ that initiates transcription of the ___________ gene producing a protein that can prevent solute entry and preserve the osmotic integrity of the cell.
|
EnvZ, OmpR, OmpF
The bacterial system that responds to changes in solute concentrations features many of the mechanisms that characterize multicellular eukaryote signaling systems.
|
|
Estrogen and testosterone are steroid hormones, and are most likely to bind to
|
Steroid hormones estrogen and testosterone are non-polar and can pass through the lipid bilayer without binding to a membrane receptor. Nonpolar steroid hormones bind to special receptors in the cell cytoplasm. These receptors are modified and migrate to the cell nucleus where they activate transcription.
|
|
Sending a signal through the cell membrane can lead to the production of second messengers inside the cell. What can serve as second messengers?
|
A.
cAMP
B.
Ca2+
C.
IP3
D.
NO (nitric oxide)
|
|
What are the two classifications of receptors
|
Cytoplasmic
memnrane
classified by location and function
|
|
Plasma membrane receptors
|
Ion channels
Protein Kinnase( insulin receptor)
G protein
|
