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Cards In This Set
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Regeneration (define):
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Growth of cells/tissues to replace lost structures
Compensatory growth
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How is repair different from regeneration?
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Scar formation also by deposition of collagen
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Repair and scar formation done by this process.
What signals?
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Fibrosis
GFs, cytokines
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Size of a cell population depends on what? (3)
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Cell proliferation
Differentiation
Cell death
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Labile tissue (define)
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Continuously dividing
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Quiescent tissue (define)
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Stable tissue
low levels of division (G0 stage), but can enter G1 and rapidly divide
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Permanent tissue
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Nondividing; no cell division
(neurons, cardiac, skeletal muscle)
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Stem cells: traits
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1. prolonged capacity for self-renewal
2. Asymmetric replication
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Assymetric replication (define):
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One cell retains capacity to self-replicate and one cell differentiates into mature, non-dividing cell
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Embryonic stem cell has what kind of potential?
Location?
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1. Pluripotent--can give rise to all tissues of body
2. Inner cell mass of blastocyts
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Adult stem cells
Location
Bone marrow types
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1. tissues that continuously divide
2. hematopoietic, marrow stem cells
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Function of hematopoietic stem cells
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1. make blood cell lineage
2. make bone marrow
3. tx some hematologic diseases
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Marrow stem cells
1. potential?
2. Function
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1. multipotent
2. migrate to injured tissue, generate stromal cells
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Cell cycle controlled by...
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1. GFs
2. Signals from ECM thru integrins
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The "gateway" into the cell cycle is...
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Transition into G1
G0 --> G1
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