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Related Flashcards
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Cards In This Set
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Does prostate cancer always involve a high level of testosterone?
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No.
-Also note that prostate cancer is not the "direct opposite" or breast cancer |
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Name the sites of Hormone production
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 |
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Adrenal glands are a source of _____
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Androgens, which can be converted to estrogen
-important source of steroid hormones |
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What are the primary sources of estrogen and testosterone?
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Ovaries and Testes
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What does aromatase do?
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Converts androgens to estrogen
-produced by breast epithelial cells and surrounding firbroblasts. -Pharmaceutical companies are working hard to develop aromatase inhibitors |
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Provide one explanation for the heterogeneity in breast cancer?
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Probably due to the fact that estrogen is produced in different tissues (partially age dependent)In addition to the ovaries, the breast- makes estrogen (relies on androgens) conversion of androgen to Estrogen is important, not just the epithelial cells but also the fibroblasts (produce aromatase which converts androgens to estrogens)
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Location and blood supply for the adrenal glands
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 -The adrenal cortex is of mesodermal origin -The adrenal cortex is richly vascularized |
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Estradiol-17-Beta is ____
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A natural estrogen hormone found in all vertebrates
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Estrone
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Produced during menopause
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Estradiol
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Predominant form in nonpregnant females
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Estriol
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-primary estrogen of pregnancy
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Name three kinds of estrogens
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Estrone, Estradiol, Estriol
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Difference in estrogen levels between males, females, and age?
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In humans, present in both males and females though higher in women of reproductive age
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Critical Functions of Estrogens
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-Essential for development (eg of female secondary sex characteristics) and reproduction
-stimulates endometrial growth during the menstrual cycle -Increases uterine growth -responsible for the maintenance of blood vessels and the skin -Reduces brain resorption, therefore increases bone formation |
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Balance of _____ determines sex
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Estrogens to Testosteronecould play a role in the development of cancersecondary sex characteristics wont happen properly unless E and T are working in concert.
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