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Related Flashcards
Cards In This Set
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These cells arise in periosteum (postnatally in bone marrow) and are found in periosteum and endosteum
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Osteoblasts
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Bone-building cells that make and secrete collagen fibers and initiate calcification (appear as cuboidal cells on bone surface)
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Osteoblasts
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Terminally differentiated osteoblasts trapped by matrix secretion
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Osteocytes
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Mature bone cells that maintain bone tissue but no longer secrete matrix (appear as small oval cells in lacunae in matrix)
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Osteocytes
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Derived from fusion of several monocytes and concentrated in endosteum
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Osteoclasts
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Function in bone resorption (giant multinucleate cells with ruffled border)
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Osteoclasts
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Bone cells derived from mesenchyme
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Osteoblasts and osteocytes
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Includes collagen fibers and non-collagenous matrix proteins (1/3 of bone ECM)
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Organic components
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Provides bone with resilience and bility to resist stretching and twisting (does not resist compression)
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Collagen
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Contribute to compressive strength of bone
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Proteoglycans
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Glue bone cells/fibers to mineralized ground substance
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Glycoproteins
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Unmineralized bone matrix - contains collagen fibers, glycoproteins, proteoglycans
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Osteoid
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Make up 2/3 of ECM of bone; consist mainly of 2 mineral salts - calcium phosphate and calcium hydroxide
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Inorganic components - resistant to compression!
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Calcium phosphate and calcium hydroxide interact to produce....
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Hydroxyapatite
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2 types of glycoproteins:
1) mediates bone cell to matrix attachment
2) links collagen and bone minerals
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1) osteopontin
2) osteonectin
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